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Additionally, it has been shown that RC is an indicator of endothelial vasomotor dysfunction (38) that can upregulate the expression of pro-inflammatory factors (facilitate monocyte movement into the arterial wall), adhesion molecules (promote the formation of thrombus) (39), and coagulation factors (enhance the aggregation of platelets) (40)

Aging Clin Exp Res

Gopal, R

Tout d'abord, le carbone de la fonction carboxylique du substrat subit une attaque nuclophile du groupement hydroxyle de la srine dont le caractre nuclophile est augment par le rsidu histidine suite la formation d'une liaison hydrogne