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Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

doi: 10.1056/NEJMoa2301972

Interferon-gamma (IFN-) In the early stages of the disease, IFN- is more important, according to research

Additionally, macrophages can directly impede preadipocyte differentiation and stimulate the expression of pro-fibrotic factors such as -smooth muscle actin (-SMA), prompting a myofibroblast-like phenotype, an effect that is potentiated by excess glucocorticoid exposure (193)
