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doi: 10.1590/S1677-5538.IBJU.2015.02.07 77 KessopoulouEPowersHJSharmaKKPearsonMJRussellJMCookeIDet al
The UPR consists of three main signaling pathways, PERK, IRE-1, and ATF6., that normally bound by a chaperone called Grp78 and are inactive
doi: 10.1038/nm1477
A plausible explanation for such adaptations is that these processes reduce stress-induced mutations in mtDNA, which is important as they lack protective histones or repair mechanisms
