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Although TRPC1 alone functions as a SOCE in human adult retinal pigment epithelial-19 (ARPE-19) cells (Bollimuntha et al., 2005), TRPC3 and 4 only function as SOCE when co-expressed with TRPC1 (de Souza and Ambudkar, 2014)

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Secondary areas include cardiovascular protection and organ protection in toxicity models

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