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Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al

ADH1B rs1229984 was significant in European Americans, whereas ADH1B rs2066702 was in African Americans [121]

The discovery that early glycolytic intermediates could be used to fuel CFE also resulted in new systems combining multiple energy substrates and metabolic pathways in the extract

A study in 2022 used this model to screen out a novel ALK5 inhibitor, TP-008, which reduced collagen deposition in mouse pulmonary fibrosis models by 70% (Luttens et al., 2025)
