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Similarly, chronic treatment with 3-AR agonists have been shown to decrease adiposity and improve insulin resistance in obese rodents (224, 225)
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After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity [21]) and reaching pre-arrival body weights (~38g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation
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