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Description
Our double-layered protein nanoparticles incorporating the full-length spike protein and the S2 stem induced robust and long-term immune responses and exhibited a safety profile in our primary studies, providing an option for current SARS-CoV-2 vaccine development. The pandemic is far from over, and new variants continue to emerge and pose a massive threat to human health
Jun 27 2011;91(12):1333-9
To accommodate clinical manufacturing requirements, CVA21 purification was scaled-up and demonstrated at 100 L and 250 L process scales across seven batches (Table 2)
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