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In addition, the effect of low-dose naltrexone (4.5 mg/day) on daily self-reported pain and overall life satisfaction, positive mood, sleep quality and fatigue was investigated in a small cohort of patients [89]

J Pharmacol Exp Ther 1999;290:1482-92

PLoS ONE 4(5): e5268

Although some therapeutic benefits appear to exhibit more statistical significance than clinical meaning, the seemingly tiny improvement in these trials is capable of being replicated
