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While researchers note that the LD50 (lethal dose) for GHK-Cu in murine models equates to an impossibly massive single dose of roughly 23,000mg for a 70kg human adultrendering acute lethal toxicity highly improbable at the standard aesthetic therapeutic doses of 5-50mgthe long-term cumulative effects of daily copper peptide injections remain entirely unmapped in human populations

Pfizer purchased exclusive global commercialization rights for the then-experimental treatment in December 2014 for $295 million upfront and a promise of up to $275 million in milestones

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