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Homocysteine can either be remethylated to methionine or metabolized to cysteine through a transsulfuration pathway requiring vitamin B 6

B12 deficiency starts with low levels in the blood and then affects the cells

doi: 10.1016/j.bbalip.2012.08.016 129 Vzquez-AnM.CassidyT.McCulloughP.VargaG