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These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimers disease

Davis KAS, Bishara D, Perera G, Molokhia M, Rajendran L, Stewart RJ