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6.5.1 Technological innovations in exposure assessment 6.5.1.1 Advanced analytical technologies Single-cell omics approaches enable detection of EED-induced epigenetic changes in individual sperm cells, providing unprecedented precision in exposure assessment ( 6.5.2 Development of targeted therapeutic interventions 6.5.2.1 Molecular-level interventions CRISPR/dCas9-based epigenetic correction represents a promising strategy for reversing EED-induced DNA methylation changes that compromise reproductive function ( 6.5.3 Strengthening international collaboration 6.5.3.1 Global policy coordination Harmonization of international regulatory standards for EED exposure limits and biomonitoring protocols remains essential for effective global health protection ( The integration of technological innovation, policy development, and individual-level interventions offers the greatest promise for effectively mitigating EED-related reproductive health risks and protecting future generations from environmental endocrine disruption

31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%

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Albers CN, Ellegaard-Jensen L, Hansen LH, Srensen SR (2018) Bioaugmentation of rapid sand filters by microbiome priming with a nitrifying consortium will optimize production of drinking water from groundwater