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The copper peptide uglies typically manifest as: Increased breakouts (microcomedones being pushed to the surface faster) Temporary redness or irritation A rough, uneven texture Skin that looks "tired" or dull for a few weeks If this is true purging, it should resolve within four to six weeks, which aligns with your skin's natural renewal cycle

10.1016/J.NEURON.2011.05.033 [DOI] [PMC free article] [PubMed] [Google Scholar] Hoyle NP, ONeill JS (2015) Oxidation-reduction cycles of peroxiredoxin proteins and nontranscriptional aspects of timekeeping