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While myo-inositol may have potential therapeutic benefits, the current evidence suggests that it is most effective when used in combination with other supplements such as selenium
Gupta, S., Samra, D., & Agrawal, S

Mice subjected to 6 weeks of prolonged stress followed by 6 weeks of social isolation exhibit symptoms of depression, accompanied by elevated levels of astrocyte activation in the dorsal and ventral dentate gyrus regions of the hippocampus (Woodward et al., 2018)

The therapeutic administration of ergot alkaloids may cause sporadic cases of human ergotism [151]
