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Description
The lack of blood supply to the heart may cause heart attacks and the lack of blood supply to the brain accelerates the development of dementia and may lead to strokes (3, 4)
In addition, ROS can cause overactivation of phosphatidylinositol 3-kinase (PI3K) eAkt by suppressing the activity of the upstream negative regulator phosphatase and tensin homolog (PTEN) in tumor cells [14]
Nausea is most common during dose escalation
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