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Today the gold standard in assessment of kidney function and estimation of glomerular filtration rate (GFR) is serum creatinine level, however, it is still imperfect due to the impact of a number of additional factors including diet, muscle mass and metabolism, gender, drugs, hydration status, where normal serum creatinine is of limited use 20

To regulate HIF-1 expression, one possibility is through growth factors signaling pathways, such as the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway or mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway

Wheat flour is made up of starch, 3 water-soluble protein groups and 2 nonsoluble protein groups

Biocatalysis typically operates under mild conditions, with pH levels close to the natural environment