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doi: 10.1016/j.tins.2018.04.005 8

For example, an increase in ACSL4 expression promotes the accumulation of polyunsaturated fatty acids (PUFAs), which enhances the sensitivity of cells to ferroptosis ( Figure 1 )
Park KH, Kim SW, Kim KD, Paick JS

Remarkably, a single mutation in the ND4 subunit of complex I is adequate to trigger LHON, as elucidated in a study on mice