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Inhibition of this pathway under normal conditions phenocopied a hyperglycemic state by enhancing chemotherapeutic efficacy in mouse PDAC, while rescuing the pathway under high glucose abrogated the anti-tumor effects observed with chemotherapy
In general, the pattern is to increase mood and libido and to decrease appetite
d Dixon et al., e Tang and Yang, 2013
Thus, non-NMDA-Rs activation is necessary to depolarize the neurons allowing NMDA-Rs activation
