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During protein folding stress, the sirtuin SIRT7 also plays an important role by contributing to repressing nuclear respiratory factor 1 (NRF1) activity, a major transcriptional regulator of mitochondrial genes

The use of humanized mice was required, as it is well-established that human albumin binds poorly to mouse FcRn 13,70,71,72,73

It is somewhat analogous to the programs that contain and carry out the information that runs your computer, yet much more sophisticated and complex