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For seventeen years, Aimee experienced headaches, memory loss, personality changes, exercise intolerance, dizziness, and light and sound sensitivity

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One case of heterogeneity is due the up regulation in endothelial cells, associated with tumours, of the PI3K/AKT pathway which has been reported in some intra tumour endothelial cells [72] , one of the consequences is the variable response to angiogenic factors like VEGF and to their blockage [73]
