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The improved efficacy of the combination therapy could be due to the ability of CoQ10 to restore endogenous antioxidants and the potential of metformin to improve mitochondrial function and decrease oxidative damage
Particular focus is shifted towards the impact of antioxidants, such as NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, which maintain the disulfide-thiol balance in the cell [37]
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Future efforts will benefit from interdisciplinary approaches, novel platforms, and deeper insight into hostfungus interactions
