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328 Our previous study showed that EBV-LMP1 activates PKC to promote the nuclear entry of annexin A2 and induce DNA synthesis and cell proliferation

By inhibiting pyruvate kinase M2 and 6phosphofructo-2kinase/fructose-2,6bisphosphatase bifunctional enzyme that generates fructose 2,6bisphosphate, Sglutathionylation promotes PPP and facilitates formation of NADPH(H + ), which increases the GSH level by increasing the activity of glutathione reductase, an enzyme that reduces GSSG using NADPH(H + ) as a coenzyme [91, 92]

Conversely, supplementation of antioxidants alone does not cure the infection and can sometimes even favor the survival of infected cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Pidugu L.S., Flowers J.W., Coey C.T., Pozharski E., Greenberg M.M., Drohat A.C