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Once released, mtDNA can be internalized into endolysosomal compartments through processes like phagocytosis, autophagy, or uptake of EVs [125, 126])
Hexokinase inhibitors like 2-deoxyglucose (2-DG) disrupt glycolysis and induce cell death in cancer cells [52, 59]
Glutathione regulates melanin production by inhibiting tyrosinase, the enzyme that triggers pigmentation
Phase 3 TRIUMPH trials and future dosing Retatrutide has not yet received regulatory approval
