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Although the structure and transcriptional regulation of mtDNA differ from nDNA, emerging evidence suggests that mtDNAnDNA interactions are essential for cellular homeostasis and developmental competence in mammalian biology [6, 7]

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In Alzheimer disease specifically, BDNF deficits are most pronounced in the hippocampus, entorhinal cortex, and prefrontal cortex, the regions earliest and hardest hit by the disease

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