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The differential parent-of-origin DNA methylation patterns at imprinted genes are established during gametogenesis where DNA of the male and female gametes acquire either maternal- or paternal-specific methylation patterns before fertilization (although some parent-of-origin methylation patterns may also continue to develop post-zygotically) (Supplemental Fig

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes

GPCR researchers are interested in looking at the ways signaling molecules bind and interact with GPCRs, the kinetics of these interactions (binding kinetics), working out which G protein subunit is coupled to a specific GPCR, looking at how some ligands selectively activate some signaling pathways while blocking others (GPCR-biased agonism), or revealing the many downstream effects that ultimately lead to a functional response within a cell