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In addition, the exercise-induced increase of catecholamines (adrenaline, noradrenaline, dopamine) also play a role in the generation of ROS [11], as well as ROS derived from endothelium [12] (Figure 1)
In women with diabetes, both oral and transdermal estrogen, with or without progestin, reduce fasting glucose, improve insulin resistance, and decrease LDL/high-density lipoprotein-cholesterol ratio (331)

so, the knowledge about the RBC antioxidant system has evolved over time, and should continue to grow, focusing on the importance of CAT, GPx and Prx2 working together in ROS detoxification and also their potential role in the erythrocyte membrane

Fatigue, brain fog, poor sleep, and mood shifts can tag along when the gut is inflamed
