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doi: 10.1007/s13311-021-01081-y 152

CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues

This was based on in vitro data showing that the presence of alcohol impacted the pattern of release for TROKENDI XR (higher concentrations sooner and potentially leading to subtherapeutic concentrations later)

A deep understanding of the pathogenic mechanisms of PD is of crucial importance for overcoming the limitations of current single-target therapies and for developing synergistic treatment strategies capable of simultaneously intervening at multiple key nodes (Fig