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However, they demonstrate high selectivity for glutamate in comparison to other structurally similar amino acids, such as aspartate or glutamine

However, none of these is present in all people with IPF and therefore do not provide a completely satisfactory explanation for the disease

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Catalyzed by DNA methyltransferases (DNMT1, DNMT2, DNMT3a, DNMT3b), it involves the transfer of a methyl group from S-adenosylmethionine (SAM) to the 5 carbon position of cytosine residues, subsequently silencing gene expression by impeding transcription factor binding