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3.7.1 Immunomodulation and barrier reinforcement A fundamental mechanism shared by Lactobacillus and Bifidobacterium species involves the modulation of host immunity through cytokine regulation ( Table 2 )

From the article: We have identified a specific signal that is generated in visceral fat, released into the blood that gets through the blood brain barrier and into the brain where it activates microglia and impairs cognition. Visceral fat as the ring leader: They looked further and found that just transplanting the visceral fat caused essentially the same impact as obesity resulting from a high-fat diet, including significantly increasing brain levels of interleukin-1 beta and activating microglia

Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis

intestinalis including gene products (highlighted in gray) contributing to the biosynthesis of glutathione [GCLC, GCLM, GSS, GGT1, xCT (SLC7A11)], its use as a redox buffer [GLRX, GPX1, GSR], and as a conjugate in phase II detoxification [GSTA1, GSTM1, GSTP1, MRP2 (ABCC2)], as well as known transcriptional regulators [NRF2 (NFE2l2), KEAP1, MAFF, BACH1, LXRA (NR1H3), FXR (NR1H4), and RXRA]