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Investigated for its ability to restore retinal function in degenerative conditions like Retinitis Pigmentosa

doi: 10.1007/s11906-012-0306-3

For CCK knockdown experiments, 8-week-old male KI mice received bilateral injections (200 nL per hemisphere) of either rAAV-CamKII-mCherry-5miR-30a-shRNA ( Cck )-3-miR30a-WPREs or a scrambled control (rAAV-CamKII-mCherry-5miR-30a-shRNA (scamble)-3-miR30a-WPREs) (BrainVTA, Wuhan, China)

It disrupts the inhibitory interaction between DPP8/9 and the inflammasome sensor NLRP1 (NLR family member, pyrin domain containing 1), leading to NLRP1 inflammasome formation, and subsequently cell death