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References 1.Peitzsch C., Gorodetska I., Klusa D., Shi Q., Alves T.C., Pantel K., Dubrovska A

LEBLANC, G.A

Beyond impairments in cavernosal relaxation, ROS accumulation and oxidative stress linked to AGE formation promote reductions in antioxidant responses, lipid peroxidation, DNA damage, and oxidative protein modifications [37,38]

In addition to targeting VEGF/VEGFR signaling, rhamnetin also interferes with the function of HIF-1, a transcription factor that becomes stabilized in hypoxic tumor environments and drives the expression of VEGF and other pro-angiogenic genes
