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Description
These medications either work on the neurotransmitter systems of serotonin (5-HT), Norepinephrine (NE), and dopamine (DA) or they suppress the action of the enzyme monoamine oxidase (MAO) to produce antidepressant effects (Harmer et al., 2017)
This is paralleled by altered NMDA receptor function, where Pb acts as a noncompetitive antagonist, modifying subunit-specific receptor sensitivity and interfering with binding at sites typically regulated by zinc
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