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Involved in cellular signaling and regulating calcium levels, CD38 degrades NAD + , using it as a co-substrate for its enzymatic activity 135,136
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A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)
