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Among the neurotoxin-induced models, MPTP and 6-OHDA are the most prevalent and widely applied to simulate the pathological features of acute PD
10.7326/0003-4819-142-1-200501040-00110 57 MitchelR

Ischemia can trigger both apoptotic and necrotic cell death pathways
(2017) demonstrated that the peptide promotes vascular endothelial growth factor receptor 2 (VEGFR2) internalisation and activates the VEGFR2-Akt-eNOS axis in human endothelial cells, rat hindlimb ischaemia, and chick chorioallantoic membrane assays [PubMed]
