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In parallel, zinc rapidly induces the expression and activation of lysosomal proteases cathepsin B and D, through early V-ATPase-dependent acidification and later TFEB-mediated transcription

It can also be added to food as fortifying agents, flavor intensifier or stabilizer

While selenium deficiency is a major etiological factor of Keshan disease (54), the seasonal and annual variation in disease occurrence suggested that other factors, especially an infectious agent, might be involved in addition to selenium deficiency (55)