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Description
The treatment of DKD remains particularly challenging due to its multifactorial and progressive pathophysiology, which involves a complex interplay of metabolic, hemodynamic, inflammatory, and fibrotic mechanisms[15]

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This process is proposed to be mediated by mitochondrial-associated degradation (MAD), which is analogous to the endoplasmic-reticulum-associated degradation (ERAD) pathway 68,69

Superficial anterior atlanto-occipital ligament: Anatomy of a forgotten structure with relevance to craniocervical stability
