melanotic macule labia Labial Atypical pigmented macule of the

Enhanced expression of Ki-67, topoisomerase II, PCNA, p53 and p21WAF1/Cip1 reflecting proliferation and repair activity in UV-irradiated melanocytic nevi

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Melanocytic matricoma typically presents as a sharply demarcated, small (generally smaller than 1 cm) unevenly pigmented papule or nodule, arising on sun-damaged skin of elderly individuals, with a male predominance.3,4 Histologically, it is a well-circumscribed nodular or multinodular dermal biphasic neoplasm, composed of epithelial cells with matrical differentiation and melanocytes