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In a pro-inflammatory setting, MSCs have the ability to release anti-inflammatory cytokines, including IL-10, TGF-1 and PGE2 (118), release exosomes with microRNAs with anti-inflammatory effects (136), inhibit the activation of NF-B, reduce the release of pro-inflammatory factors (139) and upregulate the expression of anti-apoptotic molecules, thereby exerting direct anti-inflammatory and anti-apoptotic effects

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