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[DOI] [PubMed] [Google Scholar] 82.Gonzlez C., Claudio Vera P.G., Carvajal J

These data, together with mechanistic work showing that insulin stimulates VEGF and IGF production while glucose primes macrophages for inflammatory cytokine release 394 , suggest that the combination of high glucose and high insulin is more deleterious than hyperglycemia alone

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30 IGF-1 is low at birth, increases throughout puberty and declines with older age, its concentration being roughly three times lower than that of IGF-2