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Some of the highly intracellularly activated metabolic pathways were Pyruvate metabolism (18/28), Glycolysis/Gluconeogenesis (17/24), Purine and Pyrimidine metabolism (20/41 and 11/21, respectively), and various amino acid metabolic pathways such as alanine, aspartate and glutamate metabolism, glycine, serine and threonine metabolism, cysteine and methionine metabolism, arginine biosynthesis, phenylalanine, tyrosine and tryptophan metabolism, and tryptophan metabolism (Fig

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A guide to thymic selection of T cells