mitochondrial l-carnitine shuttle pathway The carnitine links metabolism to histone acetylation and lipogenesis The Carnitine shuttle system for
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It might take as short as a few day after cessation of carnitine, cardiac arrhythmia and cardiac arrest might come suddenly leading to fatal outcome.23,24 On the other hand, it is uncertain if asymptomatic carrier (with one mutation) should be treated with carnitine

[9] Eder, K., Felgner, J., Becker, K., & Kluge, H

Administration of exogenous carnitine as an adjunct to VPA therapy is thought to restore beta-oxidation to mitochondria cells of the liver, accept toxic acyl moieties from CoA, and relieve the inhibition of urea synthesis.[3] However, our findings suggested that the effective utilization of levocarnitine transport into mitochondria, which may be individually different, might play an important role to lead these favorable processes
