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Compared with placebo, topically applied CBD significantly reduced intense pain, sharp pain, cold, and itchy sensations caused by peripheral neuropathy and showed a strong trend for reducing deep pain

( currents by activating the GABA A receptor and that approximately one-third of the magnitude of the inward currents was evoked by 100 M GABA in HNs

Additionally, it reduces the levels of brain inflammatory mediators (TNF-, IL-6, and NF-B) and -galactosidase while downregulating the gene expression of senescence pathway activators (p53-p21/p16 signaling pathway) and simultaneously elevating AMPK mRNA expression levels

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