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Effect of proline supplementation on anti-oxidative capacity, immune response and stress tolerance of juvenile Pacific white shrimp, Litopenaeus vannamei

Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax:Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity

for example TP53 deletion in fibroblasts is found to diminish senescence and to increase TGF-1 expression, leading to enhanced activated fibroblasts, more extracellular matrix deposition, reduced immune surveillance, and increased fibrosis [66]
