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Both in vivo studies in mice and in vitro studies in cultured human aortic endothelial and vascular smooth muscle cells have shown that physiological levels of TMAO induce expression of inflammatory cytokines and adhesion molecules

Int J Dev Neurosci 28:127132 Al-sharefi A, Bilous R (2015) Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency

Hence the body does not gain energy from muscle protein but from its own stored fat

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