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Graves disease, also known as autoimmune hyperthyroidism or toxic diffuse goiter, is a chronic ailment that directly affects the persons thyroid gland

ATO induces significant oxidative DNA damage in normal skin fibroblasts, triggering the ATM- Ataxia-Telangiectasia and Rad3-Related (ATR)-Chk checkpoint pathway and leading to cell cycle arrest [316]

doi: 10.3390/fire7120469 203 MainLCWolkowAPTaitJLDella GattaPRainesJSnowRet al

Most are claimed as inhibitors, but later it is discovered that they generate a neomorphic surface on E3 ligase thus inducing proximity between the E3 ligase and a neo-substrate, leading to the degradation of the latter 205