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Importantly, these effects were achieved even though treatment was not initiated until 18 mo of age
Transforming growth factor 1 (TGF-1) activates hepcidin mRNA expression in hepatocytes
10.3390/nu16244296 291 TianK.-M.LiJ.-J.XuS.-W
This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)
