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8 A 12-week Phase 2 study generated optimistic results and press coverage, with an early report suggesting that participants on the best-performing dose lost meaningfully more weight than placebo the sort of signal that justifies advancing a candidate

Vegetarians and vegans, who do not consume animal products, are also considered at risk of B12 deficiency

Early in the morning, before you have any food and before you reach for your early bird pick-me-up cup of coffee seems to work for many people, but any time in the day (as long as you stay consistent!) should get the job done

Factors such as your baseline weight, activity level, nutrition, and metabolism all play a role in your outcomes