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SASP-induced disruption of the microglial secretome results in the alteration of the homeostatic balance necessary for proper neuronal function, leading to an increase in molecules such as IL-6, IL-1, TNF-, an increase in inflammasome-related proteins and ROS, as well as increased expression of Nox2 by microglia (Ritzel et al., 2015
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References Noctor, G., Cohen, M., Trmulot, L., et al
