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it modulates the expression of over 4,000 human genes, including those responsible for inflammation control, DNA repair, collagen and elastin synthesis, antioxidant defense, and stem cell activity

However, aggregate data and covariates of interest (eg, sex, disease severity) are not consistently reported across randomised clinical trials (RCTs).6 The use of individual patient data (IPD) has several advantages, such as it allows for the exploration of the relationship between treatment effects and patient-level characteristics, and it overcomes restrictions in using the information reported in the publication among others

It may result from vascular injury during graft surgery or the hosts immune system attacking the graft tissue

The two-tailed unpaired t-tests were used for single comparisons, and the analysis of variance (ANOVA) with Tukeys multiple comparison test was used for multiple comparisons