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Finally, we discuss emerging strategies to interrogate and modulate this circuit using integrated omics, CRISPR-based screening, and pharmacological approaches, emphasizing the need for context-aware and temporally controlled metabolic interventions to enhance T cellbased immunotherapies in solid tumors
Nat Rev Genet (2007) 8(8):6019
Metformin: from mechanisms of action to therapies
In addition, 5hmC suppression induced by L2HG treatment is partially restored by DMF treatment (Fig
